Migeon, Barbara
Females Are Mosaics : X Inactivation and Sex Differences in Disease
Introduction.
Section I. Background.
1. Sex Differences in Disease
2. Evolution of the Human Sex Chromosomes and a Portrait of the Human X
3. Overview: X Chromosome Dosage Compensation
4. The Discovery of X Chromosome Inactivation and the Lyon Hypothesis
5. Experimental Models for X Inactivation Studies
Section II. Themes and Variations.
6. Theme 1: The Initial Steps: Creating the Active and Inactive X
7. Theme 2: The Subsequent Steps: Spreading Silence Along the X and Maintaining It
8. Variations 1: Stability of the Inactive X
9. Variations 2: Choice of Active X
Section III. Medical Consequences.
10. Medical Consequence 1: The Single Active X
11. Medical Consequence 2: Cellular Mosaicism
12. Determinants of Female Phenotypes
References.
List of Tables.
Glossary.
Index.
Section I. Background.
1. Sex Differences in Disease
2. Evolution of the Human Sex Chromosomes and a Portrait of the Human X
3. Overview: X Chromosome Dosage Compensation
4. The Discovery of X Chromosome Inactivation and the Lyon Hypothesis
5. Experimental Models for X Inactivation Studies
Section II. Themes and Variations.
6. Theme 1: The Initial Steps: Creating the Active and Inactive X
7. Theme 2: The Subsequent Steps: Spreading Silence Along the X and Maintaining It
8. Variations 1: Stability of the Inactive X
9. Variations 2: Choice of Active X
Section III. Medical Consequences.
10. Medical Consequence 1: The Single Active X
11. Medical Consequence 2: Cellular Mosaicism
12. Determinants of Female Phenotypes
References.
List of Tables.
Glossary.
Index.
Keywords: MEDICAL / Genetics MED107000
- Author(s)
- Migeon, Barbara
- Publisher
- Oxford University Press
- Publication year
- 2007
- Language
- en
- Edition
- 1
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (PDF)
- 9780199720064