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Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries 
Författare  
Utgivare  John Wiley and Sons, Inc.
Utgivningsår  2004
Språk  en
Utgåva  1
Förlag  Wiley-Interscience
Kategori  Organisk
Pris  172,60 €

     ISBN 9780471460725
 
 
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Skriva ut  30 sidor with an additional page accrued varje dag, capped at 30 sidor
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Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
  • Specific oligosaccharide structures used in signal transduction processes
  • Preparation and screening of glycopeptide libraries
  • Solid-phase carbohydrate synthesis
 
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