Genetics of Colorectal Cancer

I. Epidemiology and Models of Colorectal Cancer

1. Colorectal Cancer: Epidemiology
John D. Potter, David Hunter

2. Mouse Models of Intestinal Cancer
Erin M. Perchiniak, Joanna Groden

II. Pathways to Colorectal Cancer

3. The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer
Robert Gryfe

4. DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis
Joanne P. Young, Peter W. Laird

5. Pathways and Pathology
Jeremy R. Jass

III. Germline Susceptibility – Mendelian and Other Syndromes

6. Familial Adenomatous Polyposis
Julian A. Sanchez, Graham Casey, James M. Church

7. DNA Mismatch Repair and Lynch Syndrome
Brittany C. Thomas, Matthew J. Ferber, Noralane M. Lindor

8.
MUTYH-Associated Polyposis
Spring Holter, Steven Gallinger

9. Familial Colorectal Cancer Type X
Noralane M. Lindor

10. Families with Serrated Neoplasia of the Colon
Joanne P. Young

11. Peutz–Jeghers Syndrome
Douglas L. Riegert-Johnson, Lisa A. Boardman

12. Juvenile Polyposis
Kara A. Mensink, Jeremy R. Jass, Noralane M. Lindor

13.
BLM Mutation and Colorectal Cancer Susceptibility
Beatriz Russell, Joanna Groden

14. The Role of p53 in Colorectal Cancer
Serena Masciari, Sapna Syngal

15. Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer
John D. Potter

IV. Germline Susceptibility – Gene-Environment Interactions

16. Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia
Amy Y. Liu, Cornelia M. Ulrich

17. Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia
Elizabeth M. Poole, James T. Cross, John D. Potter, Cornelia M. Ulrich

18. The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer
Loïc Le Marchand

19. Calcium and Vitamin D
Roberd M. Bostick, Michael Goodman, Eduard Sidelnikov

Nyckelord: Biomedicine, Cancer Research, Human Genetics, Oncology