The Immune Synapse as a Novel Target for Therapy

1. The immune synapse and T cell activation: regulation by chemokines
Emmanuel Donnadieu

2. The induction of regulatory T cells by targeting the immune synapse
Luis Graca

3. Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
Paul J. Fairchild

4. Targeting CD4 for the induction of dominant tolerance
Herman Waldmann, Elizabeth Adams, Stephen Cobbold

5. Anti-CD3: from T cell depletion to tolerance induction
Damien Bresson, Matthias Herrath

6. Immune modulation by CD40L blockade
Yuan Zhai, Jerzy W. Kupiec-Weglinski

7. CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
Francesca Fallarino, Carmine Vacca, Claudia Volpi, Maria T. Pallotta, Stefania Gizzi, Ursula Grohmann, Paolo Puccetti

8. Adhesion molecules as therapeutic targets
Mark R. Nicolls, Rasa Tamosiuniene

9. E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
Irene Puga, Fernando Macian

10. FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
Bin Li, Xiaomin Song, Arabinda Samanta, Kathryn Bembas, Amy Brown, Geng Zhang, Makoto Katsumata, Yuan Shen, Sandra J. Saouaf, Mark I. Greene

11. Transforming growth factor-ß: From its effect in T cell activation to a role in dominant tolerance
Ramireddy Bommireddy, Thomas Doetschman

12. From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic
Wan-Fai Ng, John D. Isaacs

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000