Targeted Interference with Signal Transduction Events

1. Introduction: The Rationale for the Development of Targeted Drugs in Cancer Therapy
Bernd Groner

2. Identifying Critical Signaling Molecules for the Treatment of Cancer
Constadina Arvanitis, Pavan K. Bendapudi, Pavan Bachireddy, Dean W. Felsher

3. Tyrosine Kinase Inhibitors and Cancer Therapy
Srinivasan Madhusudan, Trivadi S. Ganesan

4. Targeting ERBB Receptors in Cancer
Nancy E. Hynes

5. Inhibition of the IGF-I Receptor for Treatment of Cancer. Kinase Inhibitors and Monoclonal Antibodies as Alternative Approaches
Yan Wang, Qun-sheng Ji, Mark Mulvihill, Jonathan A. Pachter

6. Inhibition of the TGF-ß Signaling Pathway in Tumor Cells
Klaus Podar, Noopur Raje, Kenneth C. Anderson

7. The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition
Anne Boulay, Heidi A. Lane

8. The Ras Signalling Pathway as a Target in Cancer Therapy
Kathryn Graham, Michael F. Olson

9. The Mitogen-Activated Protein Kinase Pathway for Molecular-Targeted Cancer Treatment
Judith S. Sebolt-Leopold, Roman Herrera, Jeffrey F. Ohren

10. Clinical Relevance of Targeted Interference with Src-Mediated Signal Transduction Events
Quan P. Ly, Timothy J. Yeatman

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000