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Devi, Lakshmi A.

The G Protein-Coupled Receptors Handbook

The G Protein-Coupled Receptors Handbook

132,60€

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ISBN: 9781592599196
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Table of contents

Part I.GPCRs: Structure and Function

1. Structure—Function Relationships in G Protein-Coupled Receptors
Dominique Massotte, Brigitte L. Kieffer

2. Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors
Peng Huang, Lee-Yuan Liu-Chen

3. GPCR Folding and Maturation
Ulla E. Petäjä-Repo, Michel Bouvier

4. Regulated Membrane Trafficking and Proteolysis of GPCRs
James N. Hislop, Mark Zastrow

Part II.GPCR Activity and Its Regulators

5. Heterotrimeric G Proteins and Their Effector Pathways
Tracy Nguyen Hwangpo, Ravi Iyengar

6. RGS Proteins
Ryan W. Richman, María A. Diversé-Pierluissi

7. G Protein-Coupled Receptor Kinases
Lan Ma, Jingxia Gao, Xiaoqing Chen

8. Regulators of GPCR Activity
Louis M. Luttrell

9. GPCR Interacting Proteins
Hongyan Wang, Catherine B. Willmore, Jia Bei Wang

Part III.GPCR Dimerization/Oligomerization

10. Biophysical and Biochemical Methods to Study GPCR Oligomerization
Karen M. Kroeger, Kevin D. G. Pfleger, Karin A. Eidne

11. Oligomerization Domains of G Protein-Coupled Receptors
Marta Filizola, Wen Guo, Jonathan A. Javitch, Harel Weinstein

12. Functional Complementation and the Analysis of GPCR Dimerization
Graeme Milligan, Juan J. Carrillo, Geraldine Pascal

13. The Role of Oligomerization in G Protein-Coupled Receptor Maturation
Michael M. C. Kong, Christopher H. So, Brian F. O’Dowd, Susan R. George

14. Receptor Oligomerization and Trafficking
Selena E. Bartlett, Jennifer L. Whistler

15. Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization
Noura S. Abul-Husn, Achla Gupta, Lakshmi A. Devi, Ivone Gomes

Part IV.Recent Developments in Drug Discovery

16. Role of Heteromeric GPCR Interactions in Pain/Analgesia
Andrew P. Smith, Nancy M. Lee

17. Conformational Plasticity of GPCR Binding Sites
Xavier Deupi, Cedric Govaerts, Lei Shi, Jonathan A. Javitch, Leonardo Pardo, Juan Ballesteros

18. De-Orphanizing GPCRs and Drug Development
Rainer K. Reinscheid, Olivier Civelli

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Author(s)
Publisher
Springer
Publication year
2005
Language
en
Edition
1
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9781592599196

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