Ehrhardt, Carsten

Drug Absorption Studies

Drug Absorption Studies


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ISBN: 9780387749013
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Table of contents

1. Perfused Organ Level/In Situ Techniques

1. Models for Skin Absorption and Skin Toxicity Testing
Ulrich F. Schaefer, Steffi Hansen, Marc Schneider, Javiana Luengo Contreras, Claus-Michael Lehr

2. Models of the Small Intestine
Brendan Griffin, Caitriona O’Driscoll

3. Drug Absorption from the Colon In Situ
Hiroaki Yuasa

4. In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa
Joseph A. Nicolazzo, Barrie C. Finnin

5. In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies
Remigius U. Agu, Michael I. Ugwoke

6. The Isolated Perfused Lung for Drug Absorption Studies
Ann Tronde, Cynthia Bosquillon, Ben Forbes

2. Cellular Level—In Vitro Models of Epithelial and Endothelial Barriers

7. In Vitro Models for Investigations of Buccal Drug Permeation and Metabolism
Tanja Obradovic, Ismael J. Hidalgo

8. In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism
Sven Deferme, Pieter Annaert, Patrick Augustijns

9. In Vitro Cellular Models for Nasal Drug Absorption Studies
Dae-Duk Kim

10. In Vitro Models of the Tracheo-Bronchial Epithelium
Carsten Ehrhardt, Ben Forbes, Kwang-Jin Kim

11. In Vitro Models of the Alveolar Epithelial Barrier
Carsten Ehrhardt, Michael Laue, Kwang-Jin Kim

12. Cell Culture Models of the Corneal Epithelium and Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies
Stephan Reichl, Ulrich Becker

13. The Conjunctival Barrier in Ocular Drug Delivery
Hovhannes J. Gukasyan, Kwang-Jin Kim, Vincent H.L. Lee

14. Inner Blood—Retinal Barrier: Transport Biology and Methodology
Ken-ichi Hosoya, Masatoshi Tomi

15. Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epithelia
George I. Gorodeski

16. In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier
Pallabi Mitra, Kenneth L. Audus

17. In Vitro Models to Study Blood-Brain Barrier Function
Gert Fricker

18. High-Throughput Screening Using Caco-2 Cell and PAMPA Systems
Cheng Li, Sam Wainhaus, Annette S. Uss, Kuo-Chi Cheng

19. Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations
Stephan A. Motz, Michael Bur, Ulrich F. Schaefer, Claus-Michael Lehr

3. Bioinformatics—In Silico Tools to Predict Drug Absorption

20. Modeling Transdermal Absorption
Dirk Neumann

21. Physiologically Based in Silico Models for the Prediction of Oral Drug Absorption
Fredrik Johansson, Ronnie Paterson

22. In Silico Modeling for Blood—Brain Barrier Permeability Predictions
Prabha Garg, Jitender Verma, Nilanjan Roy

4. Molecular/Sub-Cellular Level—Mechanistic Tools

23. Impact of Drug Transport Proteins
Tomohiro Terada, Ken-ichi Inui

24. Cloning and Functional Heterologous Expression of Transporters
Carsten Kneuer, Walther Honscha

25. The Pharmacology of Caveolae
Stuart A. Ross, William V. Everson, Eric J. Smart

26. Immortalization Strategies for Epithelial Cells in Primary Culture
David de Semir Frappart, Rosalie Maurisse, Esther H. Vock, Dieter C. Gruenert

27. Binding-Uptake Studies and Cellular Targeting
Franz Gabor, Michael Wirth

5. Regulatory Considerations

28. Drug Permeability Studies in Regulatory Biowaiver Applications
Donna A. Volpe


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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Publication year
Medicine, Health Care, Mode

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