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| Table of contents 1. Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components C. Dugave, C. Clavaud, J. Le Gal, R. Thai, M. Moutiez 2. Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands C. Clavaud, J. Le Gal, R. Thai, M. Moutiez, C. Dugave 3. Oxorhenium-Mediated Cyclization and Self-Assembly of Peptides: A Combinatorial Approach for the Selection of New Ligands of the Human Cyclophilin hCyp-18 C. Clavaud, M. Heckenroth, C. Stricane, M-A. Lelait, A. Ménez, C. Dugave 4. Thieno[3,2- Yann Brouillette, Vincent Lisowski, Jean Martinez 5. Solid-Phase Synthesis of Phosphinic Dipepetide Isosteres and β Amino Acids via Activated N-Terminal Acrylamides Florian Manzenrieder, Horst Kessler 6. Parallel Solid-Phase Synthesis of Macrocyclic Peptidomimetics Using Ru-Catalyzed Ring-Closing Metathesis and a New Application of Cross Metathesis Sylvie Beaubien, Hamid R. Hoveyda, Martin Vézina, Éric Marsault, Hugo Tremblay, Laurence Foucher, Kamel Benakli 7. High Throughput Solid Phase Parallel Synthesis of Macrocyclic Peptidomimetics E. Marsault, H. R. Hoveyda, M. L. Peterson, R. Gagnon, M. Vézina, J.F. Pinault, A. Landry, C. Saint-Louis, L. G. Ouellet, S. Beauchemin, K. Benakli, S. Beaubien, M. Brassard, Z. Wang, M. Champagne, F. Galaud, N. Fortin, D. Fortin, V. Plourde, M. Ramaseshan, S. Bhat, F. Bilodeau, D. Lonergan, R. Lan, S. Li, G. Berthiaume, L. Foucher, X. Peng, Y. Dory, P. Deslongchamps 8. Development of an Efficient Solid-Phase Synthetic Methodology to Construct a Combinatorial Library of a Potent HDAC Inhibitor Salvatore Di Maro, Jung-Mo Ahn 9. A Novel Hydrogel Functionalized with Specific Peptidomimetic Ligands for 2-D and 3-D Cell Culture Juntao Luo, Ekama Onofiok, Changying Shi, Ruiwu Liu, Kit S. Lam 10. Application of the “Libraries from Libraries” Concept to “One-bead One-compound” Combinatorial Chemistry Joseph C. Kappel, Yi C. Fan, Kit S. Lam 11. An Appreciation of the Scientific Life and Achievements of Bruce Merrifield Alexander R. Mitchell 12. The “Bip Method” for Spectroscopic Assignment of the Absolute Configuration of the Spin-Labelled, Cyclic β Karen Wright, Laurencev Dutot, Anne Gaucher, Michel Wakselman, Jean-Paul Mazaleyrat, Cristina Peggion, Fernando Formaggio, Claudio Toniolo 13. Enzyme Mechanism and Function of a Novel Plant PDI Involved in the Oxidative Folding of Cystine Knot Defense Peptides Christian W. Gruber, Maša Čemažar, Marilyn A. Anderson, David J. Craik 14. Biosynthesis of Siderophore-Peptides, A Class of Potent Antimicrobial Peptides from Enterobacteria, Requires Two Precursors Gaëlle Vassiliadis, Jean Peduzzi, Delphine Destoumieux-Garzón, Séverine Zirah, Xavier Thomas, Sylvie Rebuffat 15. Post-Translational Modification and folding of A Lasso-Type Gene-Encoded Antimicrobial Peptide Require Two Enzymes only in Sophie Duquesne, Delphine Destoumieux-Garzón, Séverine Zirah, Thomas A. Knappe, Christophe Goulard, Jean Peduzzi, Mohamed A. Marahiel, Sylvie Rebuffat 16. Synthesis and 3D-Structure of Conformationally Controlled Nucleo-Peptides Piero Geotti-Bianchini, Marco Crisma, Cristina Peggion, Alberto Bianco, Fernando Formaggio 17. Mixing Urea and Amide Bonds: Synthesis and Self-Organization of New Hybrid Oligomers Lucile Fischer, Gersande Lena, Jean-Paul Briand, Claude Didierjean, Gilles Guichard 18. Optimizing the Fold Stability of Miniprotein Sequences D. Victoria Williams, Jasper C. Lin, Brandon L. Kier, Niels H. Andersen 19. Antimicrobial Peptides Chelating Lanthanide Ions: the Case of Trichogin GA IV Analogues and Terbium(III) Mariano Venanzi, Emanuela Gatto, Lorenzo Stella, Gianfranco Bocchinfuso, Antonio Palleschi, Fernando Formaggio, Claudio Toniolo 20. Spectroscopic Characterization of the Fully-Extended, Planar, Peptide 2.0 Claudio Toniolo, Marco Crisma, Fernando Formaggio, Alessandro Moretto, Cristina Peggion, Bernard Kaptein, Quirinus B. Broxterman 21. Monitoring Peptide Folding by Time-Resolved Spectroscopies: the Effect of a Single Gly to Aib Susbtitution Mariano Venanzi, Emanuela Gatto, Gianfranco Bocchinfuso, Antonio Palleschi, Lorenzo Stella, Chiara Baldini, Fernando Formaggio, Claudio Toniolo, Basilio Pispisa 22. First Homo-Peptides Undergoing a Reversible 3 Alessandro Moretto, Marco Crisma, Fernando Formaggio, Claudio Toniolo, Ling Wu, Timothy A. Keiderling, Bernard Kaptein, Quirinus B. Broxterman 23. Molecular Modeling Approach to Achieving Erythropoietin Mimetic Peptides Yanfeng Qi, Xuefeng Gao, Liping Wang, Wei Li 24. Conformation Analysis of Parathyroid Hormone Residues Critical for Bioactivity Zhanna Potetinova, Feng Ni, Manghaiko Mayele, Ping Xu, Gordon E. Willick 25. Light-Switchable Folding/Unfolding of the Collagen Triple Helix with Azobenzene-Containing Model Peptides Ulrike Kusebauch, Lisa Lorenz, Sergio A. Cadamuro, Hans-Jürgen Musiol, Martin O. Lenz, Christian Renner, Josef Wachtveitl, Luis Moroder 26. Structural Studies of Parathyroid Hormone Analogue with C-Terminal Aldehyde Function Zhanna Potetinova, Feng Ni, Ping Xu, Gordon E. Willick 27. Synthesis and Conformational Studies of Novel, Side-Chain Protected, L-(aMe)Ser Homo-Peptides Fernando Formaggio, Cristina Peggion, Claudio Toniolo, Bernard Kaptein, Quirinus B. Broxterman, Minghong Ni, Laura Muzi, Alma Dal Pozzo 28. Introduction of N-alkyl Residues in Proline-rich Peptides: Effect on SH3 Binding Affinity and Peptide Conformation Paolo Ruzza, Chiara Rubini, Giuliano Siligardi, Rohanah Hussain, Andrea Calderan, Andrea Guiotto, Luca Cesaro, Anna M. Brunati, Arianna Donella-Deana 29. Thermodynamic Stability And Native-State Dynamics Of Porcine Pancreatic Phospholipase A Carmen Mrestani-Klaus, Knut Kölbel, Renate Ulbrich-Hofmann 30. The amyloidogenic domains of the human serum amyloid A protein -New Insights- Emanuel Perugia, Elena Monticelli, Sarah Rubinraut, Aviva Kapitkovsky, Mati Fridkin 31. Quantitating Amino Acid β-Strand Preferences, Turn Propensities and Cross-Strand Interactions in a Designed Hairpin Peptide Kelly N. Huggins, Niels H. Andersen 32. Determinants of fold stabilizing aromatic-aromatic interactions in short peptides Lisa A. Eidenschink, Brandon L. Kier, Niels H. Andersen 33. Spectroscopic analysis of synthetic PrP helix2-binding peptide constructs Luisa Ronga, Pasquale Palladino, Raffaele Ragone, Jean Martinez, Ettore Benedetti, Filomena Rossi, Muriel Amblard 34. Unique Role of Clusters of Electrostatic Attractions in Controlling the Stability of Two-stranded α-Helical Coiled-Coils J. Paul Kirwan, Stan C. Kwok, Susanna McReynolds, Janine Mills, David Osguthorpe, Robert S. Hodges 35. The Energetics of Weakly Polar Interactions in Model Tripeptides József Csontos, Richard F. Murphy, Sándor Lovas 36. Peptidomimetic Ligands for the Tandem SH2 Domain of the Syk Protein Involved in Signal Transduction Joeri Kuil, Loek T. M. van Wandelen, Nico J. de Mol, Rob M. J. Liskamp 37. Subtilisin Kexin Isozyme-1 (SKI-1): Production, purification, inhibitor design and biochemical applications Dayani Mohottalage, Natalie Goto, Ajoy Basak 38. Effects of Antifreeze Protein Fragments on the Properties of Model Membranes Hagit Kun, Gerardo Byk, Yitzhak Mastai 39. Fluorogenic Cyclooctapeptides and Metal Ion Sensing Maria Ngu-Schwemlein, Liliana Garcia, Kshawna Askew 40. The Impact of Aromatic Residues on the Tertiary Fold of Avian Pancreatic Polypeptide Nicholas Y. Palermo, József Csontos, Richard F. Murphy, Sándor Lovas 41. An Efficient Protocol for On-Resin, Vicinal Disulfide Formation: Applications to Thioredoxin Reductase Stevenson Jr Flemer, Robert J. Hondal 42. Potent and selective peptide agonists for human melanocortin receptor 5 Maria A. Bednarek, Tanya MacNeil, Rui Tang, M. Angeles Cabello, Marta Maroto, Ana Teran 43. Synthesis of a library of Ψ-stylostatins with potential antibacterial activity Carlos López, Montse Cruz, Javier Sánchez-Cespedes, Anna Diez 44. Mimicking natural globular structures with rigid scaffolds based on adamantane Nadine Pannier, John V. Frangioni, Wolfgang Maison 45. Discovery and Optimization of a TRAIL R2 Agonist for Cancer Therapy Yvonne M. Angell, Ashok Bhandari, M. Nuria De Francisco, Brian T. Frederick, Jennifer M. Green, Karen Leu, Kerstin Leuther, Reuben Sana, Peter J. Schatz, Erik A. Whitehorn, Kathy Wright, Christopher P. Holmes 46. Novel reactive site loop derived mini-serpin inhibitors of recombinant Proprotein Convertase 4 Ajoy Basak, Nausheen Shervani, Maria Kolajova, Shalini Cherla, Sarmistha Basak 47. Enzymatic ligation of peptides, peptide nucleic acids and proteins by means of sortase A Stephan Pritz, Yvonne Wolf, Oliver Kraetke, Jana Klose, Michael Bienert, Michael Beyermann 48. Jayanta Chatterjee, Oded Ovadia, Chaim Gilon, Amnon Hoffman, Dale Mierke, Horst Kessler 49. Cyclic Dimers Of C-terminal γ Ralf Schmidt, Joanne Butterworth, Dajan O'Donnell, V. Santhakumar, Mirek Tomaszewski 50. Structure-Function Relationship Study of Parathyroid Hormone (1–11) Analogues Containing D-AA A. Caporale, N. Fiori, E. Schievano, A. Wittelsberger, S. Mammi, M. Chorev, E. Peggion 51. Selective enzymatic hydrolysis of C-terminal Carmen G. Boeriu, Ivo F. Eggen, Dirk-Jan van Zoelen, Gilbert H. Bours 52. Peptide Ligation via the In-Situ Transformation of an Amide into a Thioester at a Cysteine Residue Toru Kawakami, Saburo Aimoto 53. Facile Synthesis of Glucagon-Like Peptide-1 (GLP-1) Mimetics Sun-Young Han, Martin Beinborn, Jung-Mo Ahn 54. Synthetic Peptide Vaccines: The Quest to Develop Peptide Vaccines for Influenza, HIV and Alzheimer's Disease Elisabetta Bianchi, Paolo Ingallinella, Marco Finotto, Joseph Joyce, Xiaoping Liang, Michael D. Miller, Gene G. Kinney, Gennaro Ciliberto, John W. Shiver, Antonello Pessi 55. Rational Design of Peptidomimetics for Class B GPCRs: Potent Non-Peptide GLP-1 Receptor Agonists Jung-Mo Ahn, Sun-Young Han, Eunice Murage, Martin Beinborn 56. The depsipeptide technique for the solid phase peptide synthesis: from stepwise assembly to segment condensation Irene Coin, Peter Schmieder, Michael Bienert, Michael Beyermann 57. A Novel Method for the Preparation of Peptide Thioester and its Application to Glycoprotein Synthesis Hironobu Hojo, Yuko Onuma, Yuri Akimoto, Yuko Nakahara, Yoshiaki Nakahara 58. Synthesis of 4-arylmethyl-L-histidine analogues for structure-activity studies of position 10 of CGRP D. David Smith, Michael Mao, Hayley Young, Martin Hulce 59. Solid-phase synthesis of dipeptidic and pseudo-dipeptidic potential NOS inhibitors through a side-chain anchoring approach Youness Touati-Jallabe, Abdallah Hamzé, Gilbert Bergé, Claudia Verna, Anne-Dominique Lajoix, Pierre Fulcrand, Jean Martinez, Jean-François Hernandez 60. Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups Alayne L. Schroll, Robert J. Hondal 61. A New Synthesis of (+)-Negamycin and Its Derivatives as a Potential Therapeutic Agent for Duchenne Muscular Dystrophy Treatment Yoshio Hayashi, Shigenobu Nishiguchi, Magne O. Sydnes, Thomas Regnier, Jun-ya Hasegawa, Takahiro Katoh, Tetsuya Kajimoto, Manabu Node, Yoshiaki Kiso 62. Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model Nir Qvit, Ada Hatzubai, Deborah E. Shalev, Yinon Ben-Neriah, Chaim Gilon 63. Synthesis of modified and hybrid protein derived biopolymers Jimmy J. Weterings, Selina Khan, Jan W. Drijfhout, Ferry Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel, Dmitri V. Filippov 64. SPPS of the Natural Product Chitinase Inhibitor Argifin: Library Generation and Biological Evaluation Mark J. Dixon, Ole A. Andersen, Daan M. F. van Aalten, Ian M. Eggleston 65. Development of Chemokine Receptor CXCR4 Antagonists Using Bio-mimetic Strategy Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Nami Ohashi, Kenichi Hiramatsu, Takanobu Araki, Akio Ojida, Itaru Hamachi, Zixuan Wang, Stephen C. Peiper, John O. Trent, Satoshi Ueda, Shinya Oishi, Nobutaka Fujii 66. Chemical Synthesis of the N-Terminal Cysteine-Rich Domain of Human OX40 Tami L. Raguse, Steven C Pomerantz, Jennifer F. Nemeth, Jinquan Luo, Audrey E. Baker, Jian Li, Diane Deriggi, Raymond Sweet, Marian Kruszynski 67. Stereoselective Synthesis of Peptidomimetics Based on Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi, Nobutaka Fujii 68. Development of a small molecule peptidomimetic affinity Ligand for efficient purification of the large protein Factor VIII Sebastian Knör, Burkhardt Laufer, Alexey Khrenov, Abdellah Benhida, Sabrina C. Grailly, Nathalie Beaufort, Viktor Magdolen, Charlotte A. E. Hauser, Evgueni L. Saenko, Jean-Marie R. Saint-Remy, Horst Kessler 69. Expression and Characterization of Recombinant S2 Subunit of SARS-coronavirus S Fusion Protein Zhe Yan, Kathryn V. Holmes, Robert S. Hodges 70. Synthesis of Biotinyl-TN14003, Anti-HIV Peptide Amide H. Nedev, H. U. Saragovi 71. Making double-minded peptides strong-willed? The side chain impact on the backbone conformation of Burkhardt Laufer, Jayanta Chatterjee, Andreas O. Frank, Horst Kessler 72. Deprotection of Takenao Odagami, Yuji Kogami, Hiroyuki Kouji, Yuko Tsuda, Yoshio Okada 73. Racemization-free segment condensation based on the Taku Yoshiya, Youhei Sohma, Yoshio Hamada, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso 74. Optimized Coupling Protocols for the Incorporation of Cys Derivatives during Fmoc-SPPS Guenther Loidl, Fritz Dick, Monika Mergler, Ralph O. Schoenleber 75. Further studies on peptide synthesis at high temperature Carina Loffredo, Nilson A. Assunção, M. Terêsa M. Miranda 76. Preparation of C-terminal modified peptides through alcoholysis and thiolysis mediated by metal ions Patrícia B. Proti, M. Terêsa, M. Miranda 77. Synthesis and Biological Activity of Amino Acid Esters of Acyclovir Ivanka Stankova, Tatyana Dzimbova, Stoyan Shishkov 78. Poly-(ProΨ[CH(OAc)CH T. Lama, G. Fridkin, W. D. Lubell 79. Fast Conventional Synthesis of Human ß-Amyloid (1–42) on the Symphony® and Prelude™ German Fuentes, Christina Hood, Jae H. Park, Hirendra Patel, Karen Page, Mahendra Menakuru 80. Side chain-to-Side chain Cyclization by Intramolecular Click Reaction - Building Blocks, Solid Phase Synthesis and Conformational Characterization Sonia Cantel, Jose A. Halperin, Michael Chorev, Mario Scrima, Anna M. D'Ursi, Jay J. Levy, Richard D. DiMarchi, Alexandra Le Chevalier, Paolo Rovero, Anna M. Papini 81. An Efficient Approach to Synthesize Multiple Peptides with Carboxyl C-termini Koichiro Hayashi, Sylvia Chen, Paul Opare-Addo, Ashok Khatri 82. Synthesis and Biological Activity of Novel α-Conotoxin Analogues Incorporating Substituted Proline Derivatives Christopher J. Armishaw, Anders A. Jensen, Christian Skonberg, Tommy Liljefors, Kristian Strømgaard 83. Application of Triethylsilane and Palladium-Charcoal-Induced Reductions in the Synthesis of Fmoc-Glutamic Acid Analogues Pijus K. Mandal, John S. McMurray 84. Synthesis of pyrrolo[3,2- Philippe Deaudelin, William D. Lubell 85. Improvements in the Chemical Synthesis of Insulin-Like Peptides Panagiota Tsetseni, Aggeliki Karkantzou, Spyros Markos, Kostas Barlos, Dimitrios Gatos, Kleomenis Barlos 86. Design And Parallel Synthesis Of New Bicyclic Small Molecules For Targeting The Melanocortin Receptors Byoung J. Min, Alexander V. Mayorov, Minying Cai, Erin Palmer, Victor J. Hruby 87. Fully Automated Fast Fmoc Synthesis and On-Resin Disulfide Bridge Formation with Pseudoproline Dipeptides on the Karen Page, Jae H. Park, Christina A. Hood, Hirendra Patel, German Fuentes, Mahendra Menakuru 88. Efficient Synthesis of Protected Satendra S. Chauhan, A. Varshney, B. Verma, Michael W. Pennington 89. ALLESSAN CAP - A Highly Versatile And Affordable Coupling Agent Richard Amitrano, Peter Koch, Marita Neuber, Doris Neumann, Peter Petrovic, Michael Roos, Christoph Vedder 90. Novel Analogues of Bifunctional Ligands for Opioid and Melanocortin 4 Receptor Vinod V. Kulkarni, Yeon Sun Lee, Christine Salibay, Peg Davis, Shou-wu Ma, Frank Porreca, Victor J. Hruby 91. Fmoc as a Probe in Peptide Purification Jiangli Song, Zhenchao Gao, Lanlan You, Niansheng Li, XianGang Yang, Wentao Zhang 92. 1,3,5-Triazepan-2,6-diones as Conformationally Constrained Dipeptide Mimetics. In Silico Guided Identification of sPLA2 Inhibitors Gilles Guichard, Gersande Léna, Joel Boeglin, Pascal Muller, Eric Boilard, Gérard Lambeau, Didier Rognan, Claude Didierjean 93. Proline-based diketopiperazine-scaffolds Nina Deppermann, Wolfgang Maison 94. Concept and Synthetic Approach for a Kilogram Scale Synthesis of Octa-D-Arginine Amide Nonahydrochloride Salt J. C. Califano, A. Uribe, J. L. Chang, C. L. Becker, J. J. Napier, V. Kishore, D. Zhou, G. Love, K. Gernhardt, J. C. Tolle 95. Stereoselective Synthesis 0f (3 Grazyna Weltrowska, Carole Lemieux, Nga N. Chung, Brian C. Wilkes, Peter W. Schiller 96. Highly Selective Cyclic Hexapeptides Antagonist of GPIIb-IIIa by Multiple Jayanta Chatterjee, Oded Ovadia, Grit Zahn, Luciana Marinelli, Amnon Hoffman, Horst Kessler 97. Synthesis of Laura Anderson, Priyesh Jain, Emily McIntosh, Mark L. McLaughlin 98. Solid-Phase Synthesis of 1,3,5-Trisubstituted 1,4-Diazepin-2-one Peptide Mimic Hassan S. Iden, William D. Lubell 99. General Solid-Phase Phosphopeptide Proteomis with Affinity Pull-Down Kim Larsen, Kasper K. Sørensen, Steen Gammeltoft, Knud J. Jensen 100. Synthesis and Peptide Coupling of Protected Pyrrolylalanine Aurélie A. Dörr, William D. Lubell 101. Synthesis of aryl sulfamate and phenol small peptide derivatives using a multidetachable sulfamate linker strategy Diane Fournier, Pierre-Alain Breuil, Donald Poirier 102. Phe-Aib Hydroxyethylene Dipeptide Isostere Synthesis Nicolas Genest, Susan Del Valle, Teresa Lama, Willam D. Lubell 103. Poly (vinyl alcohol)- Tarek Kassem, X. X. Zhu, William D. Lubell 104. Microwave-Assisted Synthesis of Rhodamine Fluorescent Tags Wajih B. Ben tahar, Jeffrey W. Keillor, William D. Lubell 105. A novel family of diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles. Meritxell Teixidó, Esther Zurita, Roger Prades, Teresa Tarrago, Ernest Giralt 106. New Perspective in Peptide Chemistry by Horst Kessler, Jayanta Chatterjee, Lucas Doedens, Florian Operrer, Eric Biron, Daniel Hoyer, Herbert Schmid, Chaim Gilon, Victor J. Hruby, Dale F. Mierke 107. Interactions of peptides with single-walled carbon nanotubes Zhengding Su, Ken Mui, Elisabeth Daub, Tong Leung, John Honek 108. Stimuli-responsive Peptide Self-assembly into Well-organized Nanofibers Tomoyuki Koga, Ken-ichi Kitamura, Nobuyuki Higashi 109. pH Controlled Aggregation Morphology of Aβ(16–22): Formation of Peptide Nanotubes, Helical Tapes and Amyloid Fibrils Ronald C. Elgersma, Dirk T. S. Rijkers, Rob M. J. Liskamp 110. Immobilization of Antimicrobial Peptides on Reverse Osmosis Polyamide Membranes: Potential Biofilm Inhibitors? Karin Berliner, Eyal Hershkovitz, Zeev Ronen, Roni Kasher 111. Synthesis of Polylactides with Side Chain Functionality: Ring-Opening Polymerimerization of a Homobislactone Prepared from Lysine Hiromi Kodera, Naoki Nishishita, Yoshiaki Hirano, Yoshiaki Kiso, Yoshio Hayashi 112. New Degradable Cationic Peptides for Modulated Gene Delivery Fiana Mirkin, Hadar Eini, Amos Douvdevani, Gerardo Byk 113. The Dcpm protecting group is a useful alternative to the Hmb residue Petra Henklein, René Röder, Hardy Weißhoff, Peter Henklein, Louis A. Carpino 114. Development of a RGDS-peptide modified polyurethane for tissue regeneration A. Rechichi, S. Sartori, A. Caporale, G. Ciardelli, G. Vozzi, L. Mazzucco, E. Peggion, P. Giusti 115. Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines Matthew D. Shoulders, Ronald T. Raines 116. Peptide-Chitosan Matrix: a New Multifunctional Biomaterial Motoyoshi Nomizu, Natsumi Yamagata, Mayumi Mochizuki, Yamato Kikkawa, Yuichi Kadoya 117. Effect of phosphorylation on tau aggregation using model peptides and Circular Dichroism studies Heather Palmer, Ajoy Basak 118. Peptides for prolonging youth Marc Heidl 119. The Synthesis of DAMGO-Based Potential Affinity Labels with High Mu Opioid Receptor Affinity and the Formation of Cyclic O-Alkyl Thiocarbamates Bhaswati Dattachowdhury, Thomas F. Murray, Jane V. Aldrich 120. Amino acid Derivatives of Aporphinic Alkaloid Glaucine and their antioxidant activity Maya Spasova, Stefan Philipov, Tsenka Milkova 121. Synthesis of Cyclic Tetrapeptide CJ 15,208: A Novel Kappa Opioid Receptor Antagonist Santosh S. Kulkarni, Nicolette C. Ross, Jay P. McLaughlin, Jane V. Aldrich 122. Exploring the relationship between turn geometry and allosteric antagonism of peptide mimic ligands for the prostaglandin F2α receptor C. B. Bourguet, X. Hou, S. Chemtob, W. D. Lubell 123. Optimization of the bioconvertion of the Angiotensin I Converting Enzyme inhibitors IPP and VPP Jos Schalk 124. Tailor made Pharmacokinetics of Peptides by Transient PEGylation Ulrich Hersel, Martina Kreuzer, Harald Rau, Dirk Vetter, Thomas Wegge 125. Design and Synthesis of Cyclic Arodyn Analogues by Ring-Closing Metathesis (RCM) for Kappa Opioid Receptor (KOP) Antagonists Wei-Jie Fang, Santosh S. Kulkarni, Thomas F. Murray, Jane V. Aldrich 126. Switch-Peptides as Folding Precursors in Self-Assembling Peptides and Amyloid Fibrillogenesis M. S. Camus, R. Mimna, A. Schmid, A. Chandravarkar, G. Tuchscherer, H. A. Lashuel, M. Mutter 127. BioShuttle mediated Plasmid Transfer — a Way to new genetic Intervention Rüdiger Pipkorn, Waldemar Waldeck, Bernd Didinger, Klaus Braun 128. Incorporation of a Novel, Fluorescent and Helicogenic ?-Amino Acid Into Peptaibols: Trichogin Ga IV C. Baldini, F. Formaggio, C. Toniolo, A. Toffoletti, C. Corvaja, J. -P. Mazaleyrat, K. Wright, J. -F. Lohier, M. Wakselman, B. Orioni, L. Stella, M. Venanzi 129. Seeking for α-Helical Propensity in a Receptor-Bound Conformation of Glucagon-Like Peptide-1 Eunice Murage, Martin Beinborn, Jung-Mo Ahn 130. Conformational Analysis and Folding of Transmembrane and Matrix Peptide Segments of the Mitochondrial Uncoupling Proteins: A Comparative Study Masoud Jelokhani-Niaraki, Marina V. Ivanova, Cheryl L. Newman, Elizabeth K. Young, Laura Wheaton, Bonnie L. McIntyre, Matthew D. Smith 131. Dynamics study on single and multiple β-sheets Inta Liepina, Salvador Ventura, Cezary Czaplewski, Adam Liwo 132. Homotrimeric Collagen Peptides As Model Systems For Cell Adhesion Studies Leslie Barth, Eva K. Sinner, Sergio A. Cadamuro, Christian Renner, Dieter Oesterhelt, Luis Moroder 133. Cyclic Peptide Analogs of Laminin Active Sequences Enhance the Biological Activity Shu Takaki, Kozue Kato-Takagaki, Nobuharu Suzuki, Shinya Oishi, Yamato Kikkawa, Motoyoshi Nomizu 134. Hydrophobic Peptide Segments in Soluble Proteins Competent For Membrane Insertion: Role in Amyloidogenesis Fiona Cunningham, Arianna Rath, Charles M Deber 135. Construction and Characterization of Melanocortin-2 and -4 Receptor Chimeras Krista R Wilson, Bettina Proneth, Hendrik Luesch, Sally A. Litherland, Carrie Haskell-Luevano 136. Expression of Double Transmembrane Domain GPCR Fragments for Biophysical Analysis Leah S. Cohen, Boris Arshava, Racha Estephan, Jacquelinev Englander, Melinda Hauser, Jeffrey M. Becker, Fred Naider 137. Peptide and Non-Peptide Mimetics Utilize Different Pathways for Signal Transduction Victor J. Hruby, Minying Cai, Matt Dedek, Hongchang Qu, Erin Palmer, Alexander Mayorov, Dev. Trivedi, George Tsaprailis, Yingqui Yang 138. Structural Studies on Large Fragments of G Protein Coupled Receptors Fred Naider, Alexey Neumoin, Boris Arshava, Leah S. Cohen, Jeffrey M. Becker, Oliver Zerbe 139. Isolation of the Influenza A HA2 C-terminal segment by combination of nonionic detergents Yulia A. Smirnova, Natalya V. Fedorova, Aleksander L. Ksenofontov, Larisa V. Kordyukova, Marina V. Serebryakova, Ludmila A. Baratova, Boris V. Vaskovsky 140. Molecular Imaging and Orientational Changes of Antimicrobial Peptides in Membranes Tzong-Hsien Lee, Kristopher Hall, Adam Mechler, Lisandra Martin, Jonathan Popplewell, Gerry Ronan, Marie-Isabel Aguilar 141. Glycated-CD59 antigen: exploration of synthetic approaches S. Cantel, A. Kavishwar, M. Schlimme, A. Khatri, J. A. Halperin, M. Chorev 142. A combination of ligand SAR and receptor site-directed mutagenesis reveals requirements for antagonist activity at the melanocortin-3 receptor Bettina Proneth, Federico P. Portillo, Carrie Haskell-Luevano 143. Conformational Effects of Cyclic Hexapeptides for Ion Channel Properties Junichi Taira, Satoko Imamura, Satoshi Osada, Masoud Jelokhani-Niaraki, Tsuguhisa Ehara, Hiroaki Kodama 144. Synthesis and Biological Activities of Cyclic Peptide, Hymenamide Analogs Yasuhiro Shiki, Mika Onai, Daisuke Sugiyama, Satoshi Osada, Ichiro Fujita, Hiroaki Kodama 145. Monitoring Glucagon and Glucagon Antagonist-Mediated Internalization: A Useful Approach to Study Glucagon Receptor Pharmacology Pallavi Sachdev, Laxmi Manohar Tirunagari, Dennis Kappei, Cecilia G. Unson 146. Semi-Synthetic Strategies to Obtain Glucosylated MOG to Identify Antibodies as Biomarkers in Multiple Sclerosis Disease Francesca Gori, Barbara Mulinacci, Eva Bonchi, Mario Chelli, Francesco Lolli, Anna M. Papini, Paolo Rovero 147. Photoprobe Peptides to Map the Interactions of Angiotensin II with its Receptor AT D. Fillion, G. Guillemette, R. Leduc, E. Escher 148. Synthesis and Biological Activity of Transmembrane Peptides Derived from FPR Family Receptors Daisuke Sugiyama, Ryo Hayashi, Satoshi Osada, Yuhei Hamasaki, Ichiro Fujita, Hiroaki Kodama 149. Incorporation of the Unnatural Amino Acid George Umanah, Li-Yin Huang, Peter G. Schultz, Fred Naider, Jeffrey M. Becker 150. Ion Channel Formation of Dimeric Peptide Enhanced by Electrostatic Inter-Helical Interactions Junichi Taira, Satoshi Osada, Masoud Jelokhani-Niaraki, Tsuguhisa Ehara, Hiroaki Kodama 151. Temperature-induced Ligand Contact Point Variations of the hAT J. Arsenault, M. P. La-Haye Renaud, M. Clément, D. Fillion, G. Guillemette, R. Leduc, P. Lavigne, E. Escher 152. Structural changes in the binding pocket of the liganded angiotensin II receptor AT1 during activation. Martin Clément, Gaétan Guillemette, Richard Leduc, Emanuel Escher 153. Vaccine delivery utilizing liposaccharides Pavla Simerska, Ross P. McGeary, Abu-Baker M. Abdel-Aal, Peter M. Moyle, Colleen Olive, Michael F. Good, Istvan Toth 154. Vaccine Delivery: Synthesis and Investigation of a Highly Pure, Multi-Epitopic Lipopeptide Vaccine Candidate Istvan Toth, Peter M. Moyle, Pavla Simerska, Yoshio Fujita, Colleen Olive, Michael F. Good 155. Synthesis of Mannosylated Glycopeptides as Components for Synthetic Vaccines Renata Kowalczyk, Margaret A. Brimble, Rod Dunbar 156. Bradykinin Analogues Acylated On Their N-terminus — Some Recent Development Dariusz Sobolewski, Adam Prahl 157. Rationally-designed Multivalent Architectures for Mimicking Homotrimers of CD40L, a Member of the TNF Superfamily Gilles Guichard, Nathalie Trouche, Sébastien Wieckowski, Weimin Sun, Olivier Chaloin, Alberto Bianco, Johan Hoebeke, Pascal Schneider, Sylvie Fournel 158. A Strategy for Selectively Shielding Portions of a Peptide/Protein from Immune Response while Maintaining Immunogenicity of Contiguous Epitopes Elisabetta Bianchi, Marco Finotto, Paolo Ingallinella, Mike Citron, Renee Hrin, Meiqing Lu, Romas Geleziunas, Michael D. Miller, Xiaoping Liang, Antonello Pessi 159. Synthesis of Peptide-Based Vaccines Zhanna Potetinova, Gordon E. Willick 160. A Peptide Vaccine Based on Retro-Inverso β-Amyloid Sequences Fails to Elicit a Cross-reactive Immune response Elisabetta Bianchi, Paolo Ingallinella, Marco Finotto, Xiaoping Liang, Gene G. Kinney, Antonello Pessi 161. Synthesis and Application of ( Kenji Tomita, Tetsuo Narumi, Ayumu Niida, ya Oishi, Hiroaki Ohno, Nobutaka Fujii 162. Gadd45β dimerization does not affect MKK7 binding Laura Tornatore, Simona M. Monti, Daniela Marasco, Nina Dathan, Rosa M. Vitale, Ettore Benedetti, Carlo Pedone, Salvatore Papa, Guido Franzoso, Menotti Ruvo 163. A Glycopeptide-based Technique for Selective Antibody Purification Elisa Peroni, Marta Tontini, Barbara Mulinacci, Mario Chelli, Francesco Lolli, Paolo Rovero, Anna M. Papini 164. C-Terminal Amidation On Aryl Hydrazine Resin Witold A. Neugebauer, Amélie Parent, Xue Wen Yuan, Robert Day 165. Synergy Between a Lead Proline-rich Antibacterial Peptide Derivative and Small Molecule Antibiotics Laszlo Jr Otvos, Marco Cassone, Vanessa de Olivier Inacio, Paul Noto, John J. Rux, John D. Wade, Predrag Cudic 166. Natural mutants of HIV CTL epitopes with enhanced immunogenicity as potential vaccine candidates Sylvie E. Blondelle, Rosa Moya, Kim Schroder, Keiko Osawa, Darcy B. Wilson 167. Lipodepsipeptide antibiotic fusaricidin and its analogues. Total solid-phase and biological activity. Maciej Stawikowski, Pedrag Cudic 168. Progress toward Total Solid-Phase Synthesis of Depsipeptide Antibiotic Katanosin B Roma Stawikowska, Maciej Stawikowski, Predrag Cudic 169. Determination of the minimal fusion peptide of HIV, SIV and BLV fusion glycoproteins Aurélien Lorin, Benoît Charloteaux, Laurence Lins, Vincent Stroobant, Robert Brasseur 170. Development of a Novel Fusion Inhibitor against T-20-resistant HIV-1 Shinya Oishi, Saori Ito, Hiroki Nishikawa, Michinori Tanaka, Hiroaki Ohno, Akira Otaka, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Nobutaka Fujii 171. ε-Peptide Chimeras as Novel Antimicrobials Yi-An Lu, Jin-Long Yang, James P. Tam 172. Chemical modifications of short antimicrobial peptides from insects and vertebrates to fight multi-drug resistant bacteria Daniel Knappe, Christin Stegemann, Ariane Nimptsch, Alexander Jr Kolobov, Ekaterina Korableva, Olga Shamova, Vladimir N. Kokryakov, Ralf Hoffmann 173. Isolation of Peptides From Rat Tissues: Peptidomics vs. Degradomics Oleg N. Yatskin, Olga V. Sazonova, Dmitry P. Khachin, Elena Y. Blishchenko, Andrei A. Karelin, Vadim T. Ivanov 174. Multivalent peptidomimetics for tumor targeting Nadine Pannier, Valerie Humblet, Preeti Misra, John Frangioni V., Wolfgang Maison 175. Comparison of [ Charlotte L. Hansen, Bertrand Kuhnast, Franciose Hinnen, Frédéric Dollé, Nic Gillings, Paul R. Hansen, Andreas Kjær 176. Carbohydrated [ Veronique Maes, Luc Brans, Christian Schweinsberg, Elisa Garcia-Garayoa, Peter Bläuenstein, Peter A. Schubiger, Dirk Tourwé 177. A Synthetic Peptide Approach for Elucidating the Points of Natural Auto-Antibody Reactivity to Proteolytic Fragments of Human IgG A. Schmidt, D. De Riggi, R. E. Jordan, B. Whitaker, G. A. Heavner, M. Kruszynski 178. Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors — A Step Towards Personal Medicine Jatinder S. Josan, Rajesh Sankaranarayanan, Heather L. Hand, Steve Fernandes, Liping Xu, Josef Vagner, Robert J. Gillies, Victor J. Hruby 179. Development of Polyvalent Peptide-Conjugated Magnetic Nanoparticles for Targeted In-Vivo Imaging of Micro-Thrombi Rana Filfil, Albert Jin, Dmitri Tolkatchev, Kenji Tonan, Richard Gingras, Philip A. Barber, Feng Ni 180. Design, Selection and Binding Mechanism of Bivalent Miniproteins Targeting Human Thrombin Andy Ng, Jamshid Tanha, Saran Narang, Feng Ni 181. Quenched Fluorescent Peptide Substrates as Tools for the Discovery of Novel Cardiovascular Disease Biomarkers A. Ian Smith, Fiona J. Warner, Rebecca A. Lew, Mike Yarski, Barry McGrath, Louise M. Burrell 182. Solid Phase Synthesis and Analysis of Amadori Peptides Andrej Frolov, David Singer, Thomas Zauner, Ralf Hoffmann 183. Design of Hetero-Bivalent Polypeptides as Kinetics-Based Sensors for High-Sensitivity Detection of Weak Molecular Interactions Kenji Tonan, Dmitri Tolkatchev, Ping Xu, Ping Wang, Josee Plamondon, Anna Vinogradova, Richard Gingras, Feng Ni 184. Monitoring of native chemical ligation by surface plasmon resonance Ewa Wieczerzak, Raymond Jr Hamel, Vincent Chabot, Vincent Aimez, Paul G. Charette, Michel Grandbois, Emanuel Escher 185. Studies for Identification of the Minimal Epitope(s) mimicked by the Synthetic Glucopeptide CSF114(Glc) Francesca Nuti, Barbara Mulinacci, Elisa Peroni, Maria C. Alcaro, Ilaria Paolini, Francesco Benedetti, Alfonso Carotenuto, Francis Ciolli, Francesco Lolli, Mario Chelli, Paolo Rovero, Anna M. Papini 186. Synthesis of Bivalent MSH Ligands and Evaluation of their Binding to hMC4R using MSH Lanthaligand Steve M. Fernandes, Rajesh Sankaranarayanan, Liping Xu, Jatinder Josan, Josef Vagner, Robert Gillies, Victor J. Hruby 187. Synthesis Of Organometallic Glycopeptides And Electrochemical Studies To Detect Autoantibodies In Multiple Sclerosis Patients'Sera. Feliciana Real-Fernández, Amélie Chamois-Colson, Jérome Bayardon, Francesca Nuti, Elisa Peroni, Maria R. Moncelli, Rita Meunier-Prest, Sylvain Jugè, Anna Maria Papini 188. Tumor Imaging With Tetrabranched Neurotensin Monica Fabbrini, Chiara Falciani, Barbara Lelli, Alessandra Cappelli, Alessandro Pini, Luisa Lozzi, Luisa Bracci 189. A new and selective radiolabeled α Stefania De Luca, Annarita Del Gatto, Menotti Ruvo, Maria Rosaria Panico, Antonella Zannetti, Silvana Del Vecchioiano, Marco Salvatore, Carlo Pedone, Michele Saviano, Laura Zaccaro 190. Ribose Building Block For The Synthesis Of Glycopeptides For Fishing Out Antibodies In Autoimmune Diseases Ma Angeles Bonache, Alexandra Le Chevalier, Francesca Nuti, Elisa Peroni, Mario Chelli, Paolo Rovero, Anna M. Papini 191. Design, Synthesis and Pharmacological Characterization of Fluorescein-Derived Endothelin Antagonists Bq-123 And Bq-788 Jean-Philippe Brosseau, Witold A. Neugebauer, Fernand Jr Gobeil, Pedro D'Orléans-Juste 192. Peptide Antagonists of the PED-hPLD1 Binding F. Viparelli, N. Doti, S.M. Monti, D. Marasco, N. Dathan, C. Pedone, C. Miele, P. Formisano, F. Beguinot, M. Ruvo 193. Jose I. Rey, Haihong Huang, Ling Sheng, Xiao Fen Zhong, Rich Meyer, Xiaohe Tong, Francis Moussy, Anita Hong 194. Photoinduced Intramolecular Covalent Bond Formation in Structurally Rigid -Bpa-(spacer)-Met Hexapeptides Alessandro Moretto, Simona Oancea, Fernando Formaggio, Claudio Toniolo, Laurence A. Huck, Dino Mangion, William J. Leigh 195. Evaluation of chemically and enzymatically prepared cross-linked BNP fragments Ganga Beligere, Huaiqin Wu, Jim Fino, Reika Campbell 196. Monitoring of MMPs activity Beata Jastrzebska, Rejean Lebel, Oliver J. McIntyre, Benoit Paquette, Witold Neugebauer, Emanuel Escher, Martin Lepage 197. Chiyi Xiong, Zhi Yang, Rui Zhang, William Tong, Juri Gelovani, Chun Li 198. PepLook: An innovative in silico tool for determination of structure, polymorphism and stability of peptides Annick Thomas, Sébastien Deshayes, Marc Decaffmeyer, Marie-Hélène Van Eyck, Benoit Charloteaux B, Robert Brasseur 199. The Effects of the EW — Peptide Optical and Chemical Isomers on the Hemopoietic Stem Cells in Intact and Irradiated Mice Vladislav I. Deigin, Tamara N. Semenets, Irina A. Zamulaeva, Yana V. Maliutina, Elena I. Selivanova, Alexander S. Saenko, Olga V. Semina 200. N-(Fluorenyl-9-methoxycarbonyl)amino Acid Amide Derivatives as a New Class of Anti-cancer Agents Lajos Gera, Daniel C. Chan, Vitalija Simkeviciene, Paul A. Jr Bunn, John M. Stewart 201. Opportunities and Challenges of Developing Peptide Drugs in the Pharmaceutical Industry Waleed Danho, Joseph Swistok, Wajiha Khan, Xin-Jie Chu, Adrian Cheung, David Fry, Hongmao Sun, Grazyna Kurylko, Leonid Rumennik, Joseph Cefalu, Gretchen Cefalu, Philip Nunn 202. Inhibition of pathogenically-related morphologic transition in Hongjian Li, Yang Li, Feng N, Zhengding Su 203. Synthesis and Pharmacological Evaluation of Highly Potent [Dmt1]DALDA Analogs P. Anantha Reddy, Anita H. Lewin, Peter W. Schiller 204. Protease-resistant glucagon like peptide-1 analogs with long-term anti-diabetes type 2 activity Hongjian Li, Cindy X Zhou, Zhengding Su 205. The discovery and development of a natural combinatorial peptide template: the cyclotides David C. Ireland, Michelle L. Colgrave, Norelle L. Daly, David J. Craik 206. Cyclic peptides as VEGF receptor antagonist Victor Goncalves, Benoit Gautier, Christiane Garbay, Michel Vidal, Nicolas Inguimbert 207. Facile Synthesis of Hydrocarbon-Stapled Peptides 208. Isolation of angiotensin I converting enzyme inhibitory peptides from a fish by-products hydrolysate Tensideal® Véronique Lahogue, Karine Vallée-Rehel, Mylène Cuart, Dominique Haras, Patrick Allaume 209. Novel Melanocortin-4 Receptor Agonists That Decrease Food Intake and Body Weight Jesse Z. Dong, Daniel B. DeOliveira, Heather A. Halem, John E. Taylor, Pierre Roubert, Pascale Plas, Michael D. Culler, Jundong Zhang 210. GHS-1a Agonists That Effectively Stimulate Food Intake and Body Weight Gain Jesse Z. Dong, Jundong Zhang, John E. Taylor, Heather A. Halem, Rakesh Datta, Michael D. Culler, John Eynon 211. Conformation-activity relationships of cyclo-constrained μ/5 opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin Jerzy Ciarkowski, Cezary Czaplewski, Sylwia Luczak, Sylwia Rodziewicz-Motowidlo, Irena Berezowska, Peter W. Schiller 212. Deltorphin analogs restricted via a urea bridge: structure and opioid activity J. Ciarkowski, A. Zieleniak, S. Rodziewicz-Motowidlo, Ł Rusak, N.N. Chung, C. Czaplewski, E. Witkowska, P. W. Schiller, J. Izdebski 213. Synthesis and Characterization of Dimeric Venom Peptides J. Vizzavona, A. Zufferey, K. Rose 214. Glycosyl-Enkephalins: Synthesis and Binding at the Mu, Delta & Kappa Opioid Receptors. Antinociception in Mice Charles M. Keyari, Brian I. Knapp, Jean M. Bidlack, John Lowey, Edward J. Bilsky, Robin Polt 215. Agonists and Partial Antagonists Acting on the Leptin—Leptin Receptor Interface Laszlo Otvos, Marco Cassone, Marianna Terrasi, Sandra Cascio, George D. Mateo, Daniel Knappe, Ralf Hoffmann, Predrag Cudic, John D. Wade, Eva Surmacz 216. Effect of 4-Fluoro-L-proline on the SH3 Binding Affinity Paolo Ruzza, Chiara Rubini, Giuliano Siligardi, Rohanah Hussain, Andrea Calderan, Andrea Guiotto, Luca Cesaro, Anna M. Brunati, Arianna Donella-Deana 217. Analogues of arginine vasopressin modified in the N-terminal part of the molecule with pipecolic acid isomers Dariusz Sobolewski, Adam Prahl, Jiřina Slaninová, Bernard Lammek 218. Analogues of arginine vasopressin modified at position 2 with proline derivatives: selective antagonists of oxytocin Dariusz Sobolewski, Adam Prahl, Jiřina Slaninová, Bernard Lammek 219. Multimeric peptides as agonists of the erythropoietin receptor Oscar Vadas, Keith Rose 220. Synthesis and Kazimierz Wisniewski, Robert Galyean, Hiroe Taki, Sudar Alagarsamy, Glenn Croston, Regent Laporte, Claudio D. Schteingart, Pierre J-M. Rivière 221. Discovery of a Ligand that Compensates for Decreased Endogenous Agonist Potency of Melanocortin-4 Receptor Polymorphisms Identified in Obese Humans Carrie Haskell-Luevano, Zhimin Xiang, Andrzej M. Wilczynski, Kimberly R. Haskell, Amy M. Andreasen, Sally A. Litherland, William J. Millard, Ira D. Pogozheva, Henry I. Mosberg, Nicholas B. Sorenson 222. High-affinity FGFR2 Binding Peptides Derived from the Native Epitope of the KGF Ligand Yijun Pan, Yvonne M. Angell, Jennifer M. Green, Kathy L. Wright, Joy Miguel, Peter J. Schatz, Christopher P. Holmes 223. Application of Intramolecular Migration Reaction in Peptide Chemistry to Chemical Biology, Chemical Pharmaceutics and Medicinal Chemistry Yoshio Hayashi, Yuri Yamazaki, Mariusz Skwarczynski, Youhei Sohma, Atsuhiko Taniguchi, Mayo Noguchi, Tooru Kimura, Saskia Neuteboom, Barbara Potts, G. Kenneth Lloyd, Yoshiaki Kiso 224. Synthesis & Biological Evaluation of PYY(3–36) Analogs Substituted with Alanine John S. Ahn, Ramina Nazarbaghi, Lawrence J. D'Souza, Soumitra Ghosh, Carolyn M. Jodka, Aung N. Lwin, Odile E. Levy 225. Development of μ/δ Opioid Ligands: Enkephalin Analogues Containing 4-Anilidopiperidine Moiety YeonSun Lee, Ravil Petrov, Vinod Kulkarni, Byoung J. Min, Shou-wu Ma, Peg Davis, Janice Oyarzo, Todd Vanderah, Josephine Lai, Frank Porreca, Ruben Vardanyan, Victor J. Hruby 226. Factors that Affect Dissociation Degree of Strong Aggregated Peptide Chains when Bound to a Polymer or Free in Solution Luciana Malavolta, Clóvis R. Nakaie 227. Development of AEZS-115 (ZEN-019) by Optimization of Structurally Unique, Orally Active, Peptidomimetic GnRH Antagonists K. W. Paulini, S. Baasner, M. Gerlach, E. E. Polymeropoulos, P. Schmidt, T. Schuster, M. Teifel, E. G. Guenther 228. Synthesis and solid-phase application of suitably protected γ-hydroxyvaline building blocks Mare Cudic, Frank Marí, Gregg B. Fields 229. Synthesis and Structure-based Dissection of Cyclic Peptide Chitinase Inhibitors: New Leads for Antifungal and Anti-Inflammatory Drugs Mark J. Dixon, Amit Nathubhai, Ole A. Andersen, Daan M. F. van Aalten, Ian M. Eggleston 230. Synthesis of Biotin-Tagged Diketopiperazine-Based Anti-Microtubule Agents and Tubulin Photoaffinity Labeling Yuri Yamazaki, Kyoko Kohno, Hiroyuki Yasui, Yoshiaki Kiso, Saskia Neuteboom, Ana M. Barral, Barbara Potts, G. Kenneth Lloyd, Yoshio Hayashi 231. Study on Interactions of Oligo(tyrosine sulfate)s with Synthetic Heparin-binding Peptides by Affinity Chromatography and MALDI-TOF-MS Miyuki Yamaguchi, Masaaki Ueki 232. Fallaxin analogues with improved antibacterial activity S. L. Nielsen, N. Frimodt-Møller, P. R. Hansen 233. Alkene/Alkane-Bridged Mimics of the Lantibiotic Nisin: Toward Novel Peptide-Based Antibiotics Rianne A. G. Harmsen, Nourdin Ghalit, Johan Kemmink, Hans W. Hilbers, Eefjan Breukink, Dirk T. S. Rijkers, Rob M. J. Liskamp 234. Peptide-Lisinopril Conjugates: Design, Synthesis and Biological Activities Josue Alfaro-Lopez, Chris Soares, Soumitra Ghosh, Alexander Kravchuk, Eugene Coates, Lynn Jodka, Amy Carroll, Que Liu 235. Novel Bifunctional Peptides as Opioid Agonists and NK-1 Antagonists Padma Nair, Takashi Yamamoto, Vinod Kulkarni, Sharif Moye, Edita Navratilova, Peg Davis, Tally Largent, Shou-wu Ma, Henry I. Yamamura, Todd Vanderah, Josephine Lai, Frank Porreca, Victor J. Hruby 236. Anti-HIV dendrimeric peptides Qitao Yu, Ling Li, James P. Tam 237. Ago-Antagonists for G Protein-Coupled Peptide Hormone Receptor by Modifying the Agonist's Signalling Domain Michael Beyermann, Nadja Heinrich, Klaus Fechner, Jens Furkert, Wei Zhang, Oliver Kraetke, Michael Bienert, Hartmut Berger 238. Model of Intermolecular Interactions between High Affinity Phosphopeptides and Stat3 John S. McMurray, Zhiyong Ren, Pijus K. Mandal, Xiaomin Chen 239. Inhibition of Stat3 by Cell-Permeable Peptidomimetic Prodrugs Targeted to its SH2 Domain John S. McMurray, Pijus K. Mandal, Warren S. Liao, Zhiyong Ren, Xiaomin Chen 240. Synthesis and Biological Activity of Conformational Restricted Galanin Fragments Marcus Marra, Marcos A. Fázio, Antonio Miranda 241. Interaction of membrane mimetic vesicles with the antimicrobial peptide gomesin and its analogues Marcela S. Carmona, Luis G. M. Moraes, Marcos A. Fázio, Rosemaire A. S. Lucca, Maria L. V. Oliva, Sirlei Daffre, Antonio Miranda 242. Limited Structure-Activity Relationships for Carboxy and AminoTerminal Substitutions of Peptide YY 25–36 David H. Singleton, James G. Boyd, Nancy A. Nardone, Brett S. Robinson, Lydia C. Pan, John R. Hadcock, A. Zane Wenzel 243. Cysteine Based PNA (CPNA): Design and Synthesis of Novel CPNA Monomers Sung Wook Yi, Priyesh Jain, Mehul Ajmera, Sridhar Reddi Kaulagari, Melissa Topper, Laura Anderson, Mark L. McLaughlin 244. Synthesis and Biological Activity of Nicotianamine and Analogues M'Barek Bouazaoui, St é phane Mari, Pierre Czernic, Catherine Curie, Jean Martinez, Florine Cavelier 245. The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and β-amino acid substrate analogs. Daniel Clayton, Iresha Hanchapola, Patrick Perlmutter, A. Ian Smith, Marie-Isabel Aguilar 246. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α-helical cationic antimicrobial peptides Ziqing Jiang, Adriana I. Vasil, John Hale, Robert E. W. Hancock, Michael L. Vasil, Robert S. Hodges 247. Action of Bauhinia-derivated compounds on Joana T. Sumikawa, Marlon V. Brito, Ana Paula U. Araújo, Maria Ligia R. Macedo, Maria Luiza V. Oliva, Antonio Miranda 248. Positively charged gramicidin A based peptides form two types of membrane channels Sergey I. Kovalchuk, Elena A. Kotova, Tatyana B. Stoilova, Sergey V. Sychev, Natalya S. Egorova, Andrey Y. Surovoy, Yuri N. Antonenko, Vadim T. Ivanov 249. Effects of Tumor-Associated Mutations in the p53 Tetramerization Domain on Oligomerization State and Transcriptional Activity Rui Kamada, Tomoko Terai, Takao Nomura, Yoshiro Chuman, Toshiaki Imagawa, Kazuyasu Sakaguchi 250. Self-association regions in the CARD of Bcl-10 M. Ruvo, A. Sandomenico, D. Marasco, S. M. Monti, B. Tizzano, A. De Capua, C. Pedone, A. Saporito, R. M. Vitale, S. Formisano, R. Stilo, D. Liguoro 251. GHRP-2 Attenuates Burn-Induced Dysfunctions in Rodents Ambikaipakan Balasubramaniam, Rashika Joshi, Lou Ann Friend, J. Howard James 252. Peptides binding the type E immunoglobulins Annamaria Sandomenico, Daniela Marasco, Simona M. Monti, Michele Saviano, Carlo Pedone, Ettore Benedetti, Menotti Ruvo 253. Evolution of the Synthetic Process to Prepare the Tripeptide Segment of ABT-510 Calvin L. Becker, Jean Christophe Califano, John C. Tolle, James J. Napier, Lawrence Kolaczkowski, Sou-Jen Chang, Zhenping Tian, Sukamar Manna 254. Retrocyclin-2: a potent anti-HIV θ-defensin that forms a cyclic cystine ladder structural motif Norelle L. Daly, Chen K. Yi, Johan K. Rosengren, Ute C. Marx, Martin L. Phillips, Alan J. Waring, Wei Wang, Robert I. Lehrer, David J. Craik 255. Isothermal Titration Calorimetry and Inhibition of Platelets Aggregation by [D-Phe/( Cristina C. Clement, Anna Babinska, Elizabeth Kornecki, Manfred Philipp 256. Trypsin Stability of Lysine-Peptoid Hybrids Trine S. Ryge, Paul R. Hansen 257. A Comparative Examination of two Fmoc Removal Reagents for Process Improvement to Produce Peptide Drugs K. Srivastava, Davis M. 258. Bicyclic Organo-Peptides as Models for Carbohydrate Binding Proteins Claudia James-Johnson, Predrag Cudic 259. Impurity Rejection in the Crystallization of ABT-510 as a Method to Establish Starting Material Specifications John C. Tolle, Calvin L. Becker, Jean C. Califano, Jane L. Chang, Kevin Gernhardt, James J. Napier, Steven J. Wittenberger, Judy Yuan 260. Spatially Defined Peptide-Polymer Biotherapeutic Synthesis on Novel Cross-linked Beads with ‘Spatially Tunable’ and ‘Isolated’ Functional Sites M.K. Jacob, K.S. Kumar 261. Supramolecular Aggregates derivatized by CCK8 Peptide as Selective Nanocarriers for Drug Delivery Antonella Accardo, Diego Tesauro, Giancarlo Morelli, Luigi Del Pozzo, Carlo Pedone, Anna Lucia Tornesello, Ettore Benedetti 262. The role of Cell Penetrating Peptides (CPPs) in membrane lipid phase behavior: a novel aspect elucidating peptide-mediated delivery Cinzia Esposito, AiWei Tian, Mario Scrima, Karolina Kieres, Pietro Campiglia, Anna Maria D'Ursi, Tobias Baumgart 263. Factors that influence oral bioavailability; A cathepsin K inhibitor for human studies Daniel F. Veber 264. Injectable Biodegradable Polymer Depots For Minimally Invasive Delivery of Peptides and Proteins Li Zhang, Steven P. Schwendeman | ||||||||||||||||||||||||
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