Angiogenesis

I. Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process

1. History of Angiogenesis
Judah Folkman

2. Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature
Donald M. McDonald

3. Endothelial Cell Activation
M. Luisa Iruela-Arispe

4. Pericytes, the Mural Cells of the Microvascular System
Gabriele Bergers

5. Matrix Metalloproteinases and Their Endogenous Inhibitors
Liliana Guedez, William G. Stetler-Stevenson

6. Integrins in Angiogenesis
Alireza S. Alavi, David A. Cheresh

II. Angiogenesis and Regulatory Proteins

7. Fibroblast Growth Factor-2 in Angiogenesis
Marco Presta, Stefania Mitola, Patrizia Dell'Era, Daria Leali, Stefania Nicoli, Emanuela Moroni, Marco Rusnati

8. Vascular Permeability/Vascular Endothelial Growth Factor
Masabumi Shibuya

9. Platelet-Derived Growth Factor
Andrius Kazlauskas

10. Angiopoietins and Tie Receptors
Pipsa Saharinen, Lauri Eklund, Kari Alitalo

11. Basement Membrane Derived Inhibitors of Angiogenesis
Michael B. Duncan, Raghu Kalluri

12. Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma
Judah Folkman

13. Thrombospondins: Endogenous Inhibitors of Angiogenesis
Paul Bornstein

III. Molecular & Cellular Mechanisms of the Angiogenic Process

14. Overview of Angiogenesis During Tumor Growth
Domenico Ribatti, Angelo Vacca

15. Hypoxic Regulation of Angiogenesis by HIF-1
Philip J. S. Charlesworth, Adrian L. Harris

16. Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2
Donald P. Bottaro, Nelly Tan, W. Marston Linehan

17. Nitric Oxide in Tumor Angiogenesis
L. Morbidelli, S. Donnini, M. Ziche

18. VEGF Signal Tranduction in Angiogenesis
Harukiyo Kawamura, Xiujuan Li, Michael Welsh, Lena Claesson-Welsh

19. Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis
Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, John S. Rudge, Nicholas W. Gale, Stanley J. Wiegand, George D. Yancopoulos

20. Immune Cells and Inflammatory Mediators as Regulators of Tumor Angiogenesis
Michele Palma, Lisa M. Coussens

21. Contribution of Endothelial Progenitor Cells to the Angiogenic Process
Marco Seandel, Andrea T. Hooper, Shahin Rafii

22. Tumor Angiogenesis and the Cancer Stem Cell Model
Chris Folkins, Robert S. Kerbel

23. Targeting the Tumor Microenvironment (Stroma) for Treatment of Metastasis
Isaiah J. Fidler, Cheryl Hunt Baker, Kenji Yokoi, Toshio Kuwai, Toru Nakamura, Monique Nilsson, J. Erik Busby, Robert R. Langley, Sun-Jin Kim

IV. Functional Assessments of Angiogenesis

24. Normalization of Tumor Vasculature and Microenvironment
Rakesh K. Jain, Dan G. Duda, Tracy T. Batchelor, A. Gregory Sorensen, Christopher G. Willett

25. Targeted Drug Delivery to the Tumor Neovasculature
Grietje Molema

26. Models for Angiogenesis
Robert Auerbach

27. Surrogates for Clinical Development
Sylvia S. W. Ng, Kim N. Chi

28. Imaging of Angiogenesis
Tristan Barrett, Peter L. Choyke

29. Tumor Endothelial Markers
Janine Stevens, Brad St. Croix

V. Clinical Translation of Angiogenesis Inhibitors

30. Overview and Clinical Applications of VEGF-A
Napoleone Ferrara

31. Protein Tyrosine Kinase Inhibitors as Antiangiogenic Agents
Alexander Levitzki

32. Therapeutic Strategies that Target the HIF System
Kristina M. Cook, Christopher J. Schofield

33. The Clinical Utility of Bevacizumab
Jeanny B. Aragon-Ching, Ravi A. Madan, James L. Gulley

34. Development of Thalidomide and Its IMiD Derivatives
Cindy H. Chau, William Dahut, William D. Figg

35. TNP-470: The Resurrection of the First Synthetic Angiogenesis Inhibitor
Hagit Mann-Steinberg, Ronit Satchi-Fainaro

36. Clinical Development of VEGF Trap
John S. Rudge, Ella Ioffe, Jingtai Cao, Nick Papadopoulos, Gavin Thurston, Stanley J. Wiegand, George D. Yancopoulos

37. Recent Advances in Angiogenesis Drug Development
Cindy H. Chau, William D. Figg

38. Combination of Antiangiogenic Therapy with Other Anticancer Therapies
Beverly A. Teicher

39. Immunotherapy of Angiogenesis with DNA Vaccines
Chien-Fu Hung, Archana Monie, T. -C. Wu

40. Challenges of Antiangiogenic Therapy of Tumors
Roberta Sarmiento, Raffaele Longo, Giampietro Gasparini

41. Pharmacogenetics of Antiangiogenic Therapy
Guido Bocci, Giuseppe Pasqualetti, Antonello Paolo, Mario Tacca, Romano Danesi

VI. Angiogenesis in Health & Disease

42. Angiogenesis in the Central Nervous System
Carmen Ruiz Almodovar, Serena Zacchigna, Peter Carmeliet

43. Lymphatic Vascular System and Lymphangiogenesis
Leah N. Cueni, Michael Detmar

44. Ocular Neovascularization
Peter A. Campochiaro

45. Angiogenesis and Pathology in the Oral Cavity
Luisa A. DiPietro

46. Revascularization of Wounds: The Oxygen-Hypoxia Paradox
Thomas K. Hunt, Michael Gimbel, Chandan K. Sen

47. Journeys in Coronary Angiogenesis
Julie M. D. Paye, Chohreh Partovian, Michael Simons

48. Perspectives on the Future of Angiogenesis Research
Douglas Hanahan

Keywords: Medicine & Public Health, Oncology, Cancer Research, Molecular Medicine, Angiology